help me plssssssss

1.Speciation, ______, results when an animal population becomes isolated by some factor, usually geographic.     

  A,form biological species       B. biological species are formed                                                 

B,which forming biological species        D. the formation of biological species

2.In some countries, acupuncture is used as an anesthesia, permitting patients to have major surgery ______.   

 A,while fully conscious           B. what is fully conscious                                               

                  C. that fully consciousness       D. which is fully conscious

3.______ that she liked curry, he would have brought her to an Indian restaurant                                   

A,If had John known             B. Were John to have know                                                              C,Were John had known                   D. Had John to know

4.Mary: "Harriet is always so considerate". _ Jane: "______ she a kind person!"

   A,Doesn't she           B. Such is       C. How is             D. Isn't